Medicine Interacting with Other Medicines
                            Q. I have COPD due to childhood asthma and pneumonia 
                              five times as a child. My chest x-ray shows small 
                              lung size and lung and bronchial scar tissue. I 
                              am a 61-year-old female. I do not have asthma attacks 
                              or lung fluids and have not been a smoker. I have 
                              tachycardia, resting pulse between 90 and 100 when 
                              not on ZIAC. My cardiologist could not determine 
                              a cause for the high pulse rate. My current medications 
                              are Adviar Diskus 250/50 and ZIAC (Bisoprolol/HCTZ 
                              ) 10/6.25mg one tab per day. 
                            I understand the beta-receptors and beta antagonists 
                              in the two medicines I take cancel the benefits 
                              of the Advair. Since starting ZIAC my resting pulse 
                              is 70-75 but my breathing quality has diminished. 
                            
                            Would switching from Advair to SPIRIVA and staying 
                              on ZIAC be something that I might benefit from? 
                              Will the ZIAC and SPIRIVA benefits cancel each other 
                              out? 
                            Sandy 
                            A. Dear Sandy, This will have to be determined 
                              by your doctor. ZIAC contains a beta-blocker, 
                              but it will not oppose Spiriva, as Spiriva is not 
                              a beta stimulator, it is an anticholinergic. 
                                
                            Dr. Tom 
                            Sleep Apnea and Asthma 
                            Q. I am 39 years old, am not overweight, and have 
                              been diagnosed with sleep apnea.  I currently 
                              use a CPAP at night, which I would describe as being 
                              moderately effective.  I also have allergies, 
                              and have been taking allergy shots for a year and 
                              a half now, which have reduced the severity of many 
                              of my allergic symptoms.  
                            How much is known about any connection between 
                              environmental allergies and sleep apnea?  I 
                              also feel shortness of breath during the daytime, 
                              though an asthma test has not shown me to have it.  
                              Is it common for sleep apnea to cause daytime shortness 
                              of breath? 
                            Keith 
                            A . Dear Keith, Not much is known about environment 
                              allergens and sleep apnea. If the allergens are 
                              causing nasal irritation, this can be contributing 
                              to upper airway obstruction and thus sleep apnea. 
                              Sleep apnea is not directly related to shortness 
                              of breath while awake. 
                            Dr. Tom 
                            Lung Treatment for Sickle Cell Anemia Patients 
                              
                            Q. Do you have any advice on the effectiveness 
                              of using EZ-PAP vs. IPPB for pediatric sickle cell 
                              anemia patients? 
                            Dee 
                            A. Dear Dee, Sorry, I have no specific information. 
                              However, if the EZ-PAP, or similar devices, can 
                              avoid nighttime oxygen reductions this could help 
                              sickle cell anemia. 
                            Dr. Tom 
                            Positive Methacholine Challenge 
                            Q. I've asked a couple of questions in the past, 
                              and have another thought for you. I'm the guy that's 
                              been worried about silicosis over the past 
                              few months. 
                            I had a methacholine challenge at St. Luke's yesterday, 
                              and after the first dose of methacholine, I had 
                              a 48% change in my lung function. After the test, 
                              I had an appointment with my pulmonary doctor who 
                              said I definitely have asthma and put me on pulmicort. 
                            
                            Any reason to doubt this diagnosis?  He said 
                              it was a very dramatic result and a very easy diagnosis 
                              for him. Sound right to you? 
                            David 
                            A. Dear David, Yes, right on. This is confirmatory 
                              of asthma, and this is not related to silicosis. 
                            
                            Dr. Tom 
                            Medications and Hair Loss 
                            Q. I am having hair loss and don't know what is 
                              causing it. I take Glipozide and Avandia for sugar 
                              diabetes and Cozaar for high blood pressure and 
                              Combivent. At first I thought it was the Zetia causing 
                              it so we discontinued that, but I am still having 
                              hair loss. Please, Dr. Tom, what do you think is 
                              causing it? If I just find out, maybe I can change 
                              medications. 
                            Marie 
                            A. Dear Marie, I do not know any connections between 
                              the medications you are taking and hair loss. 
                            Dr. Tom 
                              
                            Is "Rest" Beneficial for Bronchiectasis 
                              Patients? 
                            Q. My question is in relation to bronchiectasis 
                              patients - regarding the subject of "rest".  
                              We all know that certain parts of the body need 
                              rest to heal properly after an injury.  But 
                              what about the lungs... is 'rest' a required 
                              component in the healing process of a lung?   
                            
                            For example: if a bronchiectasis patient has a 
                              full-blown episode (fever, coughing, congestion, 
                              etc), would a bare minimum of physical activity 
                              be beneficial, or would it not matter? 
                            Paul 
                            A. Dear Paul, Rest each day is a necessity. 
                              Exercise does not worsen bronchiectasis. It is important 
                              to stay active. 
                            Dr. Tom 
                            Annual Update Concerning Lung Condition 
                              
                            Q. You answered a question for me a year or so 
                              ago. I've been diagnosed with moderate restrictive 
                              lung disease, caused by scarring from an old lung 
                              issue, and traction bronchiectasis from repeated 
                              bouts of bronchitis. 
                            As an aside, I started taking effervescent Acetylcysteine 
                              from Germany a year and a half ago. I went from 
                              two bouts of bronchitis a year, to once in the last 
                              two years. Strictly anecdotal, I know. 
                            Anyway, in my newest round of PFT's (Pulmonary 
                              Function Tests) my TLC (Total Lung Capacity, the 
                              volume of air in the lung at the end of a maximal 
                              inspiration) had actually increased from 58% 
                              to 64%, the FEV1/FVC ratio was unchanged, but the 
                              DLCO (Diffusing Capacity) went from 60% to 48%. 
                              FRC (Functional Residual Capacity, the volume of 
                              air in the lung at the end of normal expiration) 
                              and RV (Residual Volume, the volume of gas remaining 
                              in the lung at the end of a maxima l expiration) 
                              were both greatly increased. Hard to believe because 
                              I feel the best I have in two years. Of course I'm 
                              waiting for my pulmonologist's take, but thought 
                              I would ask you as well.  
                            Armand 
                            A. Dear Armand, This is good news. The small drop 
                              in the diffusion test is not alarming, and it still 
                              represents good gas exchange function. The elevated 
                              RV and FRC are also not of great concern. 
                            I believe there is increasing evidence that oral 
                              acetylcysteine can be helpful in your particular 
                              type of restrictive lung disease. Stay healthy. 
                            
                            Dr. Tom 
                            Consequence of Giving "Too" Much Oxygen 
                              
                            Q. Is it true that if you give the patient too 
                              much O2 that it will increase the CO2 in the body 
                              causing less respirations and just put the patient 
                              to sleep, permanently?  
                            JT 
                            A.  Dear JT, No. This is a very common misconception. 
                              When CO2 goes up with high concentrations of oxygen, 
                              it is NOT from a decreased drive to breath. You 
                              do not achieve high oxygen concentrations from nasal 
                              oxygen. 
                            Dr. Tom 
                            Difference Between Bronchiectasis and Chronic 
                              Bronchitis 
                            Q. What is the difference between Bronchiectasis 
                              and Chronic Bronchitis? 
                            Sandy 
                            A. Dear Sandy, They are both chronic inflammatory 
                              processes of the linings of the air passages. There 
                              is deformity and destruction of the large air passages 
                              in bronchiectasis. Bacterial infection is a far 
                              more common problem in bronchiectasis than it is 
                              in chronic bronchitis. 
                            Dr. Tom 
                            Can Granulomas be a Cyst or Adhesions? 
                              
                            Q. I have severe allergies, which have been verified 
                              through many allergy tests.  During this time 
                              of year they are especially bad and my breathing 
                              becomes strained.  I lose my breath when going 
                              up stairs and always feel as if they are struggling 
                              a bit for air.  
                            I have had the methacholine challenge and do not 
                              have asthma.  I have been taking allergy shots once 
                              a week for 7 months, and have had no improvement; 
                              in fact I think it is getting worse.  
                            I have had two chest x-rays and they shows multiple 
                              granulomas on my lungs.  I have a long history 
                              with adhesions and had a hysterectomy at 32 years 
                              old, (after many other surgeries for adhesions).  
                              I have also had a long history with polyps and cysts.  
                              Had gall bladder out- filled with polyps, had multiple 
                              cysts on ovaries, cyst in sinus etc.  
                            My concern is with my lungs and allergies.  
                              Are granulomas something to worry about?  Do 
                              they get worse with time?  Could the x-ray 
                              be wrong, and actually be adhesions or cysts and 
                              not granulomas.  Thank you for any information!  
                              I see my doctor frequently and they seem to think 
                              it isn't a big deal.  I just wanted the re-assurance.  
                            
                            Christine 
                             A. Dear Christine, Granulomas in the lung 
                              are commonly healed and of no significance. They 
                              do not relate to cysts or adhesions. Some active 
                              granulomas are present in certain allergic 
                              reactions on the lung surface, but these allergic 
                              processes are not the same as the common granulomas 
                              seen on chest x-rays. 
                            Dr. Tom 
                              
                            Worried about Husband's CT Scan 
                            Q. My husband had a chest X-ray. The doctor said 
                              that there were spots and he had a CT scan. When 
                              the doctor read the scan he said he had thickening 
                              and the spots were due to his smoking. 
                            I'm still concerned about this, my husband has 
                              a smoker's cough and has smoked for many years. 
                              I want him to see a lung doctor for a second opinion 
                              just to make sure; is this a good idea? His MD just 
                              seemed so vague in his reason for the thickening 
                              and spots. 
                            Stacey 
                            A. Dear Stacey, This all sounds vague. So-called 
                              spots are usually benign, but those that show change 
                              are suspicious of lung cancer. Better see a pulmonologist. 
                            
                            Dr. Tom 
                              
                            Brother and Sister Have Asthma, What are 
                              My Chances 
                            Q. I have not being diagnosed with asthma yet; 
                              I did however use an albuterol inhaler for about 
                              a month.  My brother has being recently diagnosed 
                              with asthma; my sister had being asthmatic 
                              since ninth grade. Is it possible for me to have 
                              asthma but not yet diagnosed? Could I be the one 
                              who has asthma as well? My family goes to the 
                              same doctor. How do I change my family physician? 
                              I am 22 years old last time I went to the doctor 
                              was in 2004 for a cough.  
                            Eric  
                            A. Dear Eric, Since your brother and sister both 
                              have asthma, you are also at risk of developing 
                              it. But this is not certain. If concerned, you should 
                              see an asthma specialist, either a pulmonologist 
                              or an allergist. 
                            Dr. Tom 
                              
                            Update from Craig 
                            Q. Thanks for your last reply (asthma, silicosis 
                              worries). You had asked me to provide you with the 
                              results of my methacholine challenge. After just 
                              one dose of the methacholine (doctor said they do 
                              as many as 4 doses to determine sensitivity) and 
                              retesting PFT's, I had a 48% decrease in lung 
                              function. 
                            They diagnosed me with asthma and gave me Pulmicort- 
                              two puffs, twice daily. I've been taking it for 
                              a week now, at least I think I'm taking it- I really 
                              can't tell if I'm inhaling anything or not, although 
                              I've followed directions.  
                            I haven't had any real change in how I feel in 
                              the past week. I have some upper abdominal aching/pain 
                              that I've had off and on for a few months sort of 
                              on my sides. Not sure if that's related or not. 
                              Seems to be. 
                            Anyway, let me know what you think about the diagnosis, 
                              and if indeed Pulmicort seems the way to go. I've 
                              heard it can take up to a month for it to fully 
                              work. Thanks as always for your time and attention. 
                            
                            Craig   
                            A. Dear Craig, Your methacholine challenge is confirmatory 
                              of asthma. Pulmicort is an anti inflammatory drug 
                              that will take some time to work. It does not treat 
                              bronchospasm, and you may need a bronchodilator, 
                              such as albuterol for symptoms. Pulmicort is a controller 
                              of asthma, and albuterol a symptom reliever. 
                            Dr. Tom